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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activationnon-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation, induced optimal T cell activationnot block OX40–OX40L interaction in contrast to clinical-stage anti-OX40 antibodies, shows superior immune-stimulating

Keywords： BGB-A445     OX40     agonistic antibody     OX40L noncompetitive    

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Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 473-480 doi: 10.1007/s11684-018-0657-5

Abstract:

Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immuneAs more and more immune receptors are found to be expressed on TAMs, the corresponding therapies may

Keywords： CD47     PD-1     PD-L1     immunotherapy     TAM     phagocytosis     macrophage    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsHowever, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associatedwith a substantial risk of immune-related adverse events (irAEs) in almost all organs or systems.

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Enhanced activation of peroxymonosulfate by CNT-TiO

Xuemin Hao, Guanlong Wang, Shuo Chen, Hongtao Yu, Xie Quan

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 5, doi: 10.1007/s11783-019-1161-0

Abstract: In this work, a UV-light assisted peroxymonosulfate (PMS) activation system was constructed with theirradiation, the photoinduced electrons generated from TiO2 could be continuously transferred to CNT for the activationcatalytic performance was ascribed to the introduction of photoinduced electrons, which could enhance the activation

Keywords： Peroxymonosulfate activation     Carbon nanotubes     TiO2     Water treatment    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Hierarchical porous carbon derived from one-step self-activation of zinc gluconate for symmetric supercapacitors

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4,   Pages 387-394 doi: 10.1007/s11705-022-2250-3

Abstract: straightforward and effective strategy is presented for producing highly porous carbons via a self-activation

Keywords： self-activation     zinc organic salts     abundant mesopores     symmetric supercapacitor     liquid electrolyte    

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Enhanced performance of oxygen vacancies on CO adsorption and activation over different phases of ZrO

Frontiers in Energy 2023, Volume 17, Issue 4,   Pages 545-554 doi: 10.1007/s11708-023-0867-7

Abstract: The effect of oxygen vacancies on the adsorption and activation of CO2 on the surface of differentThe calculations show that the oxygen vacancies contribute greatly to both the adsorption and activationFurthermore, the activation of CO2 on the ZrO2 surface where oxygen vacancies areThis finding demonstrates that the presence of oxygen vacancies promotes the activation of CO2

Keywords： CO2 activation     oxygen vacancies     ZrO2     different phases    

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A density functional theory study of methane activation on MgO supported NiM cluster: role of M on C–Hactivation

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 10,   Pages 1485-1492 doi: 10.1007/s11705-022-2169-8

Abstract: Methane activation is a pivotal step in the application of natural gas converting into high-value addedIn present work, methane activation on MgO supported Ni–M (M = Fe, Co, Cu, Pd, Pt) cluster was exploredDoping elements of the same period in Ni cluster, such as Fe, Co and Cu, for C–H bond activation followsIn addition, doping the elements of the same family, like Pd and Pt, for CH4 activation isConsequently, C–H bond activation demands a lower energy barrier on Ni–Pt cluster.

Keywords： CH4 dissociation     Ni–M     C–H bond activation     charge transfer    

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Optimal dynamic emergency reserve activation using spinning, hydro and demand-side reserves

S. Surender REDDY,P. R. BIJWE,A. R. ABHYANKAR

Frontiers in Energy 2016, Volume 10, Issue 4,   Pages 409-423 doi: 10.1007/s11708-016-0431-9

Abstract: This paper proposes an optimal dynamic reserve activation plan after the occurrence of an emergency situationThe proposed reserve activation approaches are solved using the genetic algorithm, and some of the simulationThese results demonstrate the advantage of the proposed integrated/dynamic reserve activation plan over

Keywords： demand-side reserves     dynamic reserve activation approach     hydro power units     post contingency     sequentialreserve activation approach     spinning reserves    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immuneCytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune

Keywords： hyperthermia     HPV     immune response     virus     tumor    

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SARS-CoV-2 variants, immune escape, and countermeasures

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 196-207 doi: 10.1007/s11684-021-0906-x

Abstract: Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully

Keywords： SARS-CoV-2     COVID-19     vaccine     immune escape     breakthrough     prevention    

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerMany immune checkpoints were identified in the last decade since ipilimumab, which is the first immuneHowever, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers.Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immuneIn this work, the author focuses on the combination therapy of multiple immune checkpoints (does not

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Title Author Date Type Operation

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Journal Article

Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Enhanced activation of peroxymonosulfate by CNT-TiO

Xuemin Hao, Guanlong Wang, Shuo Chen, Hongtao Yu, Xie Quan

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

Hierarchical porous carbon derived from one-step self-activation of zinc gluconate for symmetric supercapacitors

Journal Article

Enhanced performance of oxygen vacancies on CO adsorption and activation over different phases of ZrO

Journal Article

A density functional theory study of methane activation on MgO supported NiM cluster: role of M on C–Hactivation

Journal Article

Optimal dynamic emergency reserve activation using spinning, hydro and demand-side reserves

S. Surender REDDY,P. R. BIJWE,A. R. ABHYANKAR

Journal Article

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Journal Article

SARS-CoV-2 variants, immune escape, and countermeasures

Journal Article

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article